The Function and Evolution of Rabbit C Repeats

Document Type

Conference Proceeding

Publication Date

7-1995

Abstract

Within the rabbit genome, the predominant family of short interspersed repetitive elements (SINEs) are known as C repeats. These elements have been estimated to comprise approximately 12% of all rabbit nuclear DNA. Previous work characterizing 45 rabbit C revealed that this family of repeats had propagated in at least three discrete waves over the evolutionary history of rabbits. A significant number of these identified repeats were also found to provide polyadenylation signals that act to increase the stability of translated messenger RNAs. This study has focused on the characterization of additional, previously unidentified C repeats with an emphasis on further elucidating the role that they and other short repetitive elements play in eukaryotic genomes. 57 new C repeats have been found; eight of these repeats may provide polyadenylation signals; one a critical element of an essential gene's promoter.

Comments

Presented at the Ninth National Conference on Undergraduate Research, Asheville, NC, July 1995.

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