Adrian Corbett (Advisor), Barbara Hull (Committee Member), Debra Ann Mayes (Committee Member)
Master of Science (MS)
In the present study 10-12 month female rats were examined for functional recovery from stroke and this recovery was compared with the stem cell/progenitor cell proliferation in the brain (which was measured by Ki67). The cell proliferation indicated by Ki67 showed a 6 fold increase in control animals compared to the rehabilitation animals. The contralateral functional recovery in control animals were 46.6% and in the rehabilitation animals were 24.5%. The physical rehabilitation was carried out to determine if limb rehabilitation can promote greater functional recovery. The results showed that when the animals were made to over use their impaired limb compared to non-impaired limb, they experienced physical stress that decreased the stem cell/progenitor cell proliferation in the subventricular zone. This is the first study which shows that increased physical stress (due to voluntary exercise) will decrease the Ki67 levels in the subventricular zone in animals after ischemic stroke.
Department or Program
Microbiology and Immunology
Year Degree Awarded
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