Adrian Corbett (Advisor), Salim El-Amouri (Committee Member), Debra Mayes (Committee Member)
Master of Science (MS)
In this current study, we have investigated this a combination of fluoxetine, simvastatin and ascorbic acid administered daily beginning at 20-26 hours after stroke induction. We hope to understand therapeutic abilities by studying its effectiveness on the blood brain barrier permeability and gene expression changes of the microglial subtypes involved in neuro-inflammation and neurogenesis factors in the peri-infarct region. Our results indicate that S-enantiomer of fluoxetine may be more beneficial compared to the R-enantiomer. The S-enantiomer was effective in tightening the blood brain barrier in contrast to the R-enantiomer, in which the latter showed a greater Evans Blue dye permeability across the BBB studied in the cerebral cortex and cerebellum. Similarly, gene expression studies of both enantiomers compared in male and female groups confirmed the presence of microglial subtypes, and the study also showed the S-enantiomer appears to up-regulate neurogenesis growth factors and down-regulate inflammatory signals.
Department or Program
Department of Neuroscience, Cell Biology, and Physiology
Year Degree Awarded
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