Publication Date
2017
Document Type
Thesis
Committee Members
Adrian Corbett (Committee Member), Lynn Hartzler (Advisor), Barbara Hull (Committee Member)
Degree Name
Master of Science (MS)
Abstract
Stroke is one of the leading causes of deaths as the risk factors, both controllable and uncontrollable, are many. We first concentrated on a stress-free way to deliver the drugs. Our preference was to have the animals ingest the drugs, which led us to a reliable method for orally administering medication to the animal models. Using three different drug combinations, we tested the effects on neurogenesis without stroke. We found the drug combination of Fluoxetine/Statin/Ascorbic acid increases neurogenesis 19 fold when compared with control. Lastly, we looked at the gene changes in the cortex of the animal models that had been administered our drug treatment. We noted that the fluoxetine treatment group was involved in up-regulated genes showing genetic themes related to molecular functions for channel activity and that the fluoxetine/statin combination treatment group was associated with clotting activity as well as an immune response.
Page Count
115
Department or Program
Department of Biological Sciences
Year Degree Awarded
2017
Copyright
Copyright 2017, some rights reserved. My ETD may be copied and distributed only for non-commercial purposes and may not be modified. All use must give me credit as the original author.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
