Triazole Fungicide Prosaro EC 250 - induced Hematologicaland Biochemical Alterations in Male Rabbits (Oryctolagus Cuniculus)

Authors

Debabsa Rafika, Laboratory of Sciences and Technology of Water and Environment, Department of Biology, Mohamed Cherif Messadia University, Souk-Ahras, 41000, Algeria.Follow
Khaldi Fadila, Laboratory of Sciences and Technology of Water and Environment, Department of Biology, Mohamed Cherif Messadia University, Souk-Ahras, 41000, Algeria.Follow
Grara Nedjoud, Department of Biology, University 8 May 1945 Guelma, Guelma 24000, Algeria.Follow
Bouzahouane Hana, Department of Biology, Mohamed Cherif Messadia University, Souk-Ahras 41000, Algeria.Follow
Guezgouz Noureddine, Laboratory of Sciences and Technology of Water and Environment, Department of Biology, Mohamed Cherif Messadia University, Souk-Ahras, 41000, Algeria.Follow
Gheid Abdelhak, Laboratory of Sciences and Technology of Water and Environment, Department of Biology, Mohamed Cherif Messadia University, Souk-Ahras, 41000, Algeria.Follow

Abstract

The study aimed to evaluate the toxic effects of fungicide Prosaro 250 EC on hematological profiles and renal functional-biochemical markers, as well as blood glucose level .Twenty-four male rabbits were equally and randomly divided into control untreated group (G1) (n =6) received distilled water and standard food, and three treated groups (n=6 each) received by oral gavage Prosaro 250 EC at three doses (mg/kg body weight (bw)), 0.093 (G2), 0.186 (G3) and 0.465 mg/kg bw (G4) for 21 days .Results revealed a significant decrease in the kidney weight, and a significant increase in the levels of serum urea, uric acid, creatinine, and glucose in Prosaro treated groups compared with the control group. Moreover, Prosaro-induced hematotoxicity was evidenced by a marked decline inred blood cell counts (RBC), hemoglobin (HGH) and hematocrit (HT) levels, along with a significant increase in white blood cell (WBC) and platelet count. Thus the sub-chronic toxicity of Prosaro 250 EC is proved to induce hematological and biochemical alterations in rabbits.

Article History

Received: April 30,, 2022; Accepted: June 04, 2022; Published: Sep 30, 2022

Recommended Citation

Rafika, D., Fadila, K., Nedjoud, G., Hana, B., Noureddine, G., & Abdelhak, G. (2022). Triazole Fungicide Prosaro EC 250 - induced Hematologicaland Biochemical Alterations in Male Rabbits (Oryctolagus Cuniculus), Journal of Bioresource Management, 9 (3).