Title

Frequency-Dependent Synaptic Depression Modifies Postsynaptic Firing Probability in Cats

Document Type

Article

Publication Date

10-1-1998

Abstract

1. The influence of stimulus trains applied to single Ia axons on the firing behaviour of single motoneurones was assessed in anaesthetized cats. The change in motoneurone firing probability associated with a single Ia afferent spike was measured from short-latency peaks in peristimulus time histograms or cross-correlograms. Some synapses showed frequency-dependent depression of the short-latency peak, which is consonant with the frequency-dependent depression reported for the Ia-motoneurone excitatory postsynaptic potential (EPSP).

2. Where they could be measured, EPSPs superimposed on the depolarizing ramps of potential recorded from motoneurones as they fired repetitively showed frequency-dependent changes in amplitude that parallelled those of the simultaneously recorded histograms.

3. Thus it appears that at synapses with small EPSPs, which are typical in the mammalian CNS, modulation of the EPSP should result in similar modulation of cell firing.

DOI

10.1111/j.1469-7793.1998.189bf.x