Fluoride Ingestion During Pregnancy and Lactation: Morphological Effects on Maternal Rat Bone
Anorganic preparations of femurs from female rats, given 150 ppm fluoride [F-] in the drinking water for 10 wk prior to and during 1 subsequent pregnancy and lactation period, were examined by SEM [scanning electron microscopy] and compared to controls. The major difference seen was a marked increase in endosteal resorption. Presumably a decreased serum Ca concentration, caused by bone F- deposition along with a high demand on Ca under the influence of lactation, resulted in increased bone mineral mobilization from the endosteal surface.
Ream, L. J.,
Pendergrass, P. B.,
& Scott, J. N.
(1983). Fluoride Ingestion During Pregnancy and Lactation: Morphological Effects on Maternal Rat Bone. Fluoride, 16 (1), 23-33.