Fluoride Ingestion in Rats: Effects on Neonatal Bone
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Fluoride crosses the placenta and mammary gland of the rat and deposits in fetal calcified tissues. Information concerning the possibility of a morphological effect of fluoride on bone in successive litters is lacking. Rats at 3 weeks of age from the third pregnancy litters of dams given 150 ppm fluoride in the drinking water were examined for physical and morphological changes in the femur. Bone length and fresh weight were not significantly different from those of control rats from dams given distilled drinking water. Moreover, examination by light and scanning electron microscopy revealed no pathological changes in the femurs as a result of maternal ingestion of fluoride. These results indicate that the amount of fluoride crossing the placenta and mammary gland is insufficient to produce morphological changes in the bones of 3 week old rats.
Ream, L. J.,
Pendergrass, P. B.,
& Scott, J. N.
(1983). Fluoride Ingestion in Rats: Effects on Neonatal Bone. The Ohio Journal of Science, 83 (2), 104.