Title

Specific Inhibition of RH0(D) Antibody by Sialic Acids

Document Type

Article

Publication Date

11-11-1960

Abstract

Agglutination of RhO(D) erythrocytes by specific antiserum was inhibited by crude and crystalline N-acetylneuraminic acid, less inhibited by its glycoyl derivative, and weakly inhibited by its degradation product, N-acetyl-mannosamine, and by D-mannose. A brain ganglioside containing neuraminic acid and a Pseudomonas polysaccharide were even more inhibitory. Inhibition was specific for anti-D sera.

DOI

10.1126/science.132.3437.1398