Title

A Computer Model of Mammalian Central CO2 Chemoreception

Document Type

Book Chapter

Publication Date

2008

Abstract

We developed a single compartment model of a mammalian CO2 sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO2sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation.

DOI

10.1007/978-0-387-73693-8_52

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