A Computer Model of Mammalian Central CO2 Chemoreception
We developed a single compartment model of a mammalian CO2 sensitive neuron and tested the hypothesis that pH-dependent inhibition of multiple potassium channels contributes to CO2sensitivity. pH-dependent inhibition of potassium channels by either intracellular or extracellular pH was sufficient to alter neuronal activity, but changes in neither intracellular nor extracellular pH are required to elicit a neuronal response to hypercapnic stimulation.
Chernov, M. M.,
Putnam, R. W.,
& Leiter, J. C.
(2008). A Computer Model of Mammalian Central CO2 Chemoreception. Integration in Respiratory Control: From Genes to Systems, 605, 301-305.