Title

The Effect of Methanandamide on Isolated Type I Cells

Document Type

Conference Proceeding

Publication Date

2003

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Abstract

Previous work from this laboratory has demonstrated that hypoxia inhibits a TASK-1 like background K+ current in isolated neonatal rat carotid body type I cells. This inhibition leads to membrane depolarisation and voltage gated Ca2+ entry (Buckler, 1997; Buckler et al 2000). Maingret et al (2000) have demonstrated that the endocannabinoid anandamide was a direct and selective blocker of TASK-1. Therefore, in this study we have investigated the actions of anandamide and its analogue methanandamide on isolated type I cells.

Comments

Presented at the 15th International Symposium on Arterial Chemoreception, Lyon, France.

DOI

10.1007/978-1-4419-9280-2_15