Biophysical Properties of a Chloride Channel in the Apical Membrane of a Secretory Epithelial Cell
Document Type
Article
Publication Date
1988
Abstract
1. Patch clamp studies on colonic tumor cell line T84 show the presence of chloride channels.
2. The channels are activated by forskolin, PGE2, or 8-Br-cAMP.
3. Single channel conductance was ca 40 pS at the reversal potential, increasing to 70 pS at +80mV and decreasing to 25 pS at −80 mV.
4. Relative permeabilities were I > Br > Cl > F.
Repository Citation
Halm, D. R.,
Rechkemmer, G.,
Schoumacher, R. A.,
& Frizzell, R. A.
(1988). Biophysical Properties of a Chloride Channel in the Apical Membrane of a Secretory Epithelial Cell. Comparative Biochemistry and Physiology Part A: Physiology, 90 (4), 597-601.
https://corescholar.libraries.wright.edu/ncbp/988
DOI
10.1016/0300-9629(88)90673-1
