Title

Biophysical Properties of a Chloride Channel in the Apical Membrane of a Secretory Epithelial Cell

Document Type

Article

Publication Date

1988

Abstract

1. Patch clamp studies on colonic tumor cell line T84 show the presence of chloride channels.

2. The channels are activated by forskolin, PGE2, or 8-Br-cAMP.

3. Single channel conductance was ca 40 pS at the reversal potential, increasing to 70 pS at +80mV and decreasing to 25 pS at −80 mV.

4. Relative permeabilities were I > Br > Cl > F.

DOI

10.1016/0300-9629(88)90673-1