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Description

Post Herpetic Neuralgia (PHN) is a painful condition that occurs after reactivation of the dormant Herpes Zoster Virus.Typically PHN presents with a unilateral rash affecting a single dermatome which is accompanied by burning, irritation, and hypersensitivity for >3 months.Current treatment includes anticonvulsants, tricyclic antidepressants, narcotic/nonnarcotic painkillers, and topical lidocaine.

We propose the utilization of a superconcentrated transdermal patch of capsaicin called Qutenza 8%, which is 300 times more potent than current OTC capsaicin. The treatment protocol using Qutenza to treat refractory PHN proposes a novel approach to the treatment of this condition.

Capsaicin is commonly known as the active chemical in peppers which is responsible for their spiciness and the pain and irritation associated with ingesting them. The mechanism of action of capsaicin is believed to be release of neurotransmitters upon binding to capsaicin nociceptors, mainly TRPV1. At large doses, capsaicin causes depletion of neurotransmitters and can ultimately lead to nerve fiber denervation. Once the neuron is damaged or depleted of neurotransmitters, pain perception is notably diminished for a period of time thereby effectively providing relief

Publication Date

4-21-2017

Disciplines

Arts and Humanities | Engineering | Life Sciences | Medicine and Health Sciences | Physical Sciences and Mathematics | Social and Behavioral Sciences

Comments

Presented at the Eighth Annual Celebration of Research, Scholarship, and Creative Activities, Dayton, OH, April 21, 2017.