Document Type

Poster

Publication Date

8-1-2018

Identifier/URL

39890191 (Pure)

Abstract

Ultraviolet light exposure is the major cause for photodamage. Pathologic effects of UVradiation include precancerous actinic keratosis which can progress into squamous cellcarcinoma. UV exposures commonly encountered include sunlight and indoor tanning bedexposure. Actinic neoplasia (precancerous actinic keratosis and non-melanoma skincancer) are highly prevalent in elderly patients with fair skin, and those with lower immunesystems. The impact on our healthcare system is substantial, as currently the averageannual cost to treat non-melanoma skin cancer is 5 billion dollars [1]. Though often asource of considerable morbidity due to extensive surgical procedures to remove the skincancers in the normal populations, squamous cell carcinomas are a common source ofmortality in immunosuppressed populations, including solid organ transplant recipients.For prevention and accurate intervention planning, it is crucial to predict if patients haveactinic neoplasia. In this study, we investigated the change in optical properties andvascular parameters to characterize skin tissue based on photodamage. Through an IRB-approved clinical trial at the Wright State Physician’s Pharmacology Translational Unit, 55test subjects over the age of 35 years with fair skin and various levels of skin damagewere included. Their level of ultraviolet skin damage on their bilateral forearms wasphotographed and categorized by both practicing dermatologists and by non-invasivemesoscopic imaging technique Spatial Frequency Domain Imaging (SFDI). The SFDIgenerated maps of absorption, scattering, hemoglobin concentrations, and tissue oxygensaturation. Previously, our group has reported pilot studies that SFDI can be used toidentify actinic damage [2].The Dermatologists scored the same forearm image according to Global AssessmentSeverity Scale ranging from 0 (less severe) to 9 (the most progressed stage of skindamage) using a validated tool [3]. SFDI was used to assess levels of scattering andhemoglobin concentration in the subjects’ skin. The dermatologists’ scores showedagreement over the extreme stages of skin damage, but in the moderate groupings morevariance existed. Further methods to find the best statistical method will be explored,along with different criteria to correlate the SFDI results. Ideally, a non-invasive imaging(such as SFDI) will be used in clinical settings for frequent monitoring of patients at highrisk for actinic neoplasia

Comments

Presented at the 2018 Ohio Dermatological Association Annual Meeting, September 7-9, 2018 in Columbus, Ohio.

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