Publication Date


Document Type


Committee Members

Mark Anstadt (Committee Co-chair), Chandler Phillips (Committee Member), David Reynolds (Committee Co-chair)

Degree Name

Master of Science in Engineering (MSEgr)


Direct Mechanical Ventricular Actuation (DMVA) is a non-blood contacting cardiac assist device that augments ventricular function. The purpose of this study was to determine if a volume-regulated "hand pump" drive system and a pressure-regulated "switch tank" drive system provide equivalent levels of cardiac support. Canine (n=2) and swine (n=4) were instrumented for hemodynamic monitoring and intravascular echocardiography. DMVA support was assessed during both severe heart failure and fibrillation. Pump function was evaluated using hemodynamic measures to calculate stroke work. Myocardial function was assessed using echocardiographic speckle tracking to quantify strain rate. Results were compared between groups using paired t-tests. There were no significant differences in either pump function or myocardial strain rates between the hand pump versus switch tank during support of either the failing or fibrillating heart. These results suggest functional equivalency between the two drive system mechanisms that supports development of an automated volume-regulated system, with its corresponding benefits in reduced size, portability, and potential user-friendly control.

Page Count


Department or Program

Department of Biomedical, Industrial & Human Factors Engineering

Year Degree Awarded


Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.