Eric Fossum (Committee Member), David Grossie (Other), Daniel Ketcha (Advisor), Kenneth Turnbull (Committee Member)
Master of Science (MS)
Indolinones of the type known as Arylidene oxindoles have been demonstrated to possess a broad range of activity ranging from proten kinase inhibtors, cell-death inhibitors and tau protein binding agents. Small libraries of such molecules were designed and synthesized herein in modifications involving variously substituted halogen derivatives, N-alkylation of the indolinone nitrogen, and finally a new class of molecules, namely arylidene oxindoles possessing extended conjugation. The biological activities of such molecules were examined and the results disclosed herein.
Department or Program
Department of Chemistry
Year Degree Awarded
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