Publication Date


Document Type


Committee Members

Adrian Corbett (Advisor), Debra Mayes (Committee Member), Mary White (Committee Member)

Degree Name

Master of Science (MS)


Previous animal experiments have indicated that administration of fluoxetine and simvastatin at 20-26 hours post-stroke decreases the volume of ischemic infarcts. This experiment expanded on previous experiments by adding ascorbic acid to the post-stroke regimen, initiating simvastatin pre-stroke, and adding a third initiation time frame (48-54 hours). Male retired breeder Sprague-Dawley rats were on simvastatin for 7 days prior to stroke induction. Combined medications of 5 milligrams/kilogram of fluoxetine, 1 milligram/kilogram of simvastatin and 20 milligrams/kilogram of ascorbic acid were orally administered at 6-12 hours, 20-26 hours, or 48-54 hours, respectively, following stroke induction. Adult rats that were treated 20-26 hours post-stroke showed a decrease in infarct volume (15.67 ± 5.622 millimeters cubed, P=0.0098) compared to the control. The combination of simvastatin, fluoxetine and ascorbic acid decreased the relative risk (RR=0.3704 (95% confidence interval 0.0987 to 1.3905, p-value = 0.1411) of bleeding after ischemic stroke if initiated 20-26 hours after stroke induction in rats.

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Department or Program

Department of Neuroscience, Cell Biology and Physiology

Year Degree Awarded


Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.

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