Publication Date
2019
Document Type
Thesis
Committee Members
Jaime Ramirez-Vick (Advisor), Nasim Nosoudi (Committee Member), Amir Zadeh (Committee Member)
Degree Name
Master of Science in Biomedical Engineering (MSBME)
Abstract
Vascular injury is identified during pre-clinical toxicity testing within certain pharmacological classes of drug candidates and induces degenerative and hyperplastic changes in endothelial (ECs) and vascular smooth muscle (VSMCs) cells. This drug-induced vascular injury has been show as a side-effect caused by various classes of drugs, including, antibacterial (e.g., azithromycin), anti-malarial (e.g., quinoline), anti-viral (e.g., anti-hepatitis C virus interferons) and nonsteroidal anti-inflammatory drugs (e.g., ibuprofen), and affects normal cardiovascular function and can further lead to various cardiovascular conditions like arrhythmia, cardiac arrest, high blood pressure, and even heart attack. The search for agents capable of reducing vascular injury side-effects by drugs is a very active and important pharmacological field. Dietary polyphenols have been shown to protect the vasculature against drug-induced vascular injury by directly affecting both, VSMCs and ECs. We propose polyphenols like pentagalloyl glucose (PGG), punicalagin and quercetin can be an excellent choice as a vascular protectant against the injury caused by drugs used to treat disease. Our study focusses on the a) development of an ex vivo rat aortic model under a peristaltic flow, and b) testing the vascular protective effects of different polyphenols when our model system is exposed to drugs affecting the vasculature. We will focus on three polyphenols (i.e., PGG, punicalagin, and quercetin) and two drugs (i.e., acetylcholine and phenylephrine). With acetylcholine, known to induce EC-dependent vasodilation, and phenylephrine, known to induced contraction of VSMCs. Result will show the damage caused by drugs on untreated vasculature when compared to those treated with polyphenols.
Page Count
29
Department or Program
Department of Biomedical, Industrial & Human Factors Engineering
Year Degree Awarded
2019
Copyright
Copyright 2019, all rights reserved. My ETD will be available under the "Fair Use" terms of copyright law.
ORCID ID
0000-0002-0241-0500
