Ioana E. Pavel, Ph.D. (Advisor); Travis B. Clark, Ph.D. (Committee Member); Steven R. Higgins, Ph.D. (Committee Member); David A. Dolson, Ph.D. (Committee Member)
Master of Science (MS)
In this study, novel silver nanoparticles (AgNPs) were successfully synthesized and functionalized with an antibacterial agent, namely chlorothymol (denoted C@AgNPs). The resulting colloid (C@AgNPs) was purified by two comparative methods: ultrafiltration and ultracentrifugation. Ultrafiltration proved to be more efficient in purifying and size selecting (10 kD filter) and concentrating the C@AgNPs than ultracentrifugation. The physicochemical properties of the filtered C@AgNPs were then characterized by UV-Vis absorption spectroscopy, inductively coupled plasma optical emission spectroscopy (ICP-OES), Raman spectroscopy, Cytoviva hyperspectral imaging, and Scanning electron microscopy. These measurements confirmed the functionalization of the core AgNPs with chlorothymol and suggest the proposed mechanism of C@AgNP formation through a coordinate covalent bond between the oxygen atom of chlorothymol and the Ag atoms at the nano surface.
Department or Program
Department of Chemistry
Year Degree Awarded
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