Publication Date
2022
Document Type
Thesis
Committee Members
Ioana E. Pavel, Ph.D. (Advisor); Travis B. Clark, Ph.D. (Committee Member); Steven R. Higgins, Ph.D. (Committee Member); David A. Dolson, Ph.D. (Committee Member)
Degree Name
Master of Science (MS)
Abstract
In this study, novel silver nanoparticles (AgNPs) were successfully synthesized and functionalized with an antibacterial agent, namely chlorothymol (denoted C@AgNPs). The resulting colloid (C@AgNPs) was purified by two comparative methods: ultrafiltration and ultracentrifugation. Ultrafiltration proved to be more efficient in purifying and size selecting (10 kD filter) and concentrating the C@AgNPs than ultracentrifugation. The physicochemical properties of the filtered C@AgNPs were then characterized by UV-Vis absorption spectroscopy, inductively coupled plasma optical emission spectroscopy (ICP-OES), Raman spectroscopy, Cytoviva hyperspectral imaging, and Scanning electron microscopy. These measurements confirmed the functionalization of the core AgNPs with chlorothymol and suggest the proposed mechanism of C@AgNP formation through a coordinate covalent bond between the oxygen atom of chlorothymol and the Ag atoms at the nano surface.
Page Count
68
Department or Program
Department of Chemistry
Year Degree Awarded
2022
Copyright
Copyright 2022, all rights reserved. My ETD will be available under the "Fair Use" terms of copyright law.
