Adrian M. Corbett, Ph.D. (Advisor); Michael Mattot, Ph.D. (Committee Member); Christopher N. Wyatt, Ph.D. (Committee Member)
Master of Science (MS)
Using forelimb asymmetry analysis along with Montoya Staircase methodology we tested how a fluoxetine simvastatin ascorbic acid drug cocktail would affect recovery from a demyelinating event in a rat model, with the hypothesis that if administered then it would help female recovery but hinder male recovery. It was found that a fluoxetine simvastatin and ascorbic acid drug cocktail did not significantly enhance recovery from a demyelination model injury in female rats, and that the same drug cocktail significantly slowed male rat recovery from the same type of injury. It was also apparent that the more effective methodology for investigating this model further would be the Montoya staircase. This was due to compensatory behavior masking the behavioral symptoms of white matter damage in forelimb asymmetry analysis.
Department or Program
Department of Neuroscience, Cell Biology, and Physiology
Year Degree Awarded
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