Publication Date

2020

Document Type

Thesis

Committee Members

Sherif Elbasiouny, Ph.D., P.E. (Advisor); David R. Ladle, Ph.D. (Committee Member); Keiichiro Susuki, M.D., Ph.D. (Committee Member)

Degree Name

Master of Science (MS)

Abstract

Amyotrophic Lateral Sclerosis is a fatal, progressive, neurodegenerative disease. There currently is no cure for the disease and limited treatment options have modest effects. A hallmark of the disease is motoneuron degeneration. Within the membrane of motoneurons are small-conductance calcium-activated potassium channels. SK Channels function to mediate medium afterhyperpolarization period of an action potential and have substantial influence on the firing rate of motoneurons. SK channels, specifically SK2 and SK3 isoforms, have been shown through immunohistochemistry to be affected in the SOD1G93A mouse model. The goal of this study was to investigate whether neonatal administration of CyPPA, a potent SK2 and SK3 activator, had effects on the clustering of SK2 and SK3 channels in the SOD1G93A mouse model. To explore this, immunohistochemistry was performed at postnatal day 21 and day 90 and determined that CyPPA had influence on the clustering profile of both SK channel isoforms in wild-type and SOD1G93A.

Page Count

99

Department or Program

Department of Neuroscience, Cell Biology and Physiology

Year Degree Awarded

2020


Included in

Anatomy Commons

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