Publication Date
2010
Document Type
Thesis
Committee Members
Khalid Elased (Committee Member), James Lucot (Committee Member), Marianna Morris (Committee Co-chair), Richard Simman (Committee Chair)
Degree Name
Master of Science (MS)
Abstract
In Carbon Monoxide (CO) induced Delayed Neurological Sequelae (DNS) clinical signs develop 1 to 6 weeks after CO has cleared the body. The aim of this experiment was to develop a model of CO induced DNS which closely mimics "real world" conditions both in exposure and treatment. The model was challenged with hyperbaric or normobaric oxygen, or room air. Basic behaviors were measured by Open Field test on days 1, 7, 14 post exposure and treatment. No significant difference in behavior was observed between exposed and control animals or between treatment groups. Histological analyses showed no DNA or necrotic damage to the basal ganglia, cortex, or hippocampus in CO exposed animals at time of euthanasia regardless of treatment. Data suggest variability in tolerance to CO and development of DNS. Data also indicates that the in vivo COHb half-life is not constant across species.
Page Count
78
Department or Program
Department of Pharmacology and Toxicology
Year Degree Awarded
2010
Copyright
Copyright 2010, all rights reserved. This open access ETD is published by Wright State University and OhioLINK.
