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Cockpit design may have major consequences on future pilot’s tasks. Functions needed to ensure flight safety are shared between pilots and aircraft systems. Today, cockpits are designed considering a theoretical minimum level of crew resources availability although it is widely acknowledged that availability of crew resources may vary from time to time because of aircrew internal state. Therefore, it is crucial to ensure that future cockpits are designed while taking into consideration this variability. This work aims at developing a methodology enabling designer to systematically integrate crew resources availability in the design process. In order to assess the impact of different sources of variability, the principles of the systemic model FRAM is used. The present work is analyzing the impact of crew resources availability on several use cases using FRAM principles. The data are collected by the means of focus group with operational and human factors experts. Some preliminary results are presented and discussed.