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A human-in-the-loop simulation was performed to evaluate an advanced Aircraft Dependent Surveillance – Broadcast (ADS-B) application that provides runway safety indications on a Cockpit Display of Traffic Information (CDTI) implemented on a Class 2 Electronic Flight Bag (EFB). There are display limitations associated with the use of a Class 2 EFB including when the ownship symbol is shown, and how the surface moving map is displayed at various stages of flight. Nineteen pilots viewed the CDTI in a baseline condition without indications, and then in two conditions with traffic and/or runway indications while operating a mediumfidelity flight simulator. Subjective results indicate that pilots preferred a CDTI with runway indications over a baseline CDTI without such indications. Pilots reported that it was difficult to determine the location of traffic relative to ownship when the display was in North-up mode. The objective performance results showed few performance differences across display types.