Green Design of Plant Based Pharmaceutical Drugs: Example of a Wound Healing Topical Cream with Plectranthus Bojeri (Benth) Hedge Lamiaceae Extract

Authors

Helga Rim Farasoa, Faculty of Science, University of Antananarivo, 101 Antananarivo, MadagascarFollow
Marie Louise Razafindravao, High Institute of Polytechnic of Antananarivo, 101 Antananarivo, Madagascar
Rojo Fanambinantsoa Andriamiarantsoa, Hay Natiora Company, 101 Antananarivo, Madagascar
Gerard Cecilien Raboanary, High Institute of Polytechnic of Antananarivo, 101 Antananarivo, Madagascar
Jean Marie Razafindrakoto, High Institute of Agriculture, University of Antananarivo, 101 Antananarivo, Madagascar
Voahangy Ramanandraibe Vestalys, Faculty of Science, University of Antananarivo, 101 Antananarivo, Madagascar

Abstract

To ensure the perennity of natural resources, the valorisation process of herbal pharmaceuticals must be assessed for sustainability from the very beginning of its design. No specific tools have been developed for this particular field so far. We demonstrate in this study that existing green design tools can be adapted to evaluate plant-based products manufacturing process. As the example of a topical cream using Plectranthus bojeri (Benth) Hedge LAMIACEAE extract was considered, we first confirmed the traditional use of this plant for wound healing. It acts by accelerating the re-epithelialisation phase. Using the Vermeer Cosmolife version 0.24 software tool the ingredients of the cream such as sunflower oil and beeswax were judged to have no risk to the human health and the environment. A preservative containing Dehydroacetic acid initially incorporated into its formulation has been removed. The green assessment of the product design and the manufacturing process led to the conclusion that the project lacks circularity. The revalorisation of extraction waste using a biochar technology was suggested to improve this criterion. A new metric called “Plant Valorisation Efficacy Index”, noted I_VEP was also proposed. This metric represents the ratio between the quantity of biomass that needs to be processed to produce a dose of drug for one healing cure and the quantity of total biomass that can be collected from an individual plant. This value directly correlates the effect of the transformation process with the ecological status of the exploited plant allowing a better estimation of the project’s impact on resource sustainability.

Article History

Received: Mar 19, 2024; Accepted: Nov 06, 2024; Published: Dec 31, 2024

Recommended Citation

Rim Farasoa, H., Razafindravao, M., Andriamiarantsoa, R. F., Raboanary, G. C., Razafindrakoto, J., & Ramanandraibe Vestalys, V. (2024). Green Design of Plant Based Pharmaceutical Drugs: Example of a Wound Healing Topical Cream with Plectranthus Bojeri (Benth) Hedge Lamiaceae Extract, Journal of Bioresource Management, 11 (4).