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Abstract

Hawthorn (Crataegus spp.), traditionally regarded as an important medicinal plant and frequently cited in the literature, presents significant potential for sustainable development and medical biotechnology. This review looks at several areas of Hawthorn that can be explored in response to current healthcare and environmental sustainability issues. Bioactive compounds from hawthorn, including active compounds primarily comprised of flavonoids, procyanidins, and triterpenoids, are responsible for potent antioxidant, anti-inflammatory, cardio-protective, and antimicrobial activities, potentially providing a source of potent therapeutic alternatives. Moreover, hawthorn has a well-documented record as a source of cardiovascular benefits to address arterial hypertension, congestive heart failure, and arrhythmias. In consideration of sustainability, hawthorn provides distinct benefits by offering adaptation to geographic features. Hawthorn cultivation requires minimal management, as it grows without the need for fertilization, insecticides, or pesticides, and ecological features like the reduction of soil erosion and support for biodiversity all contribute to sustainability. This review explores innovative approaches of hawthorn utilization to support developing pharmaceuticals and even nutraceuticals, and functional food, and it highlights its importance in supporting the principles of green chemistry, positioning it as a valuable resource for healthcare applications, sustainable biopharmaceutical development, and ecological and economic sustainability.

Article History

Received: Jan 12, 2025; Accepted: Aug 13, 2025; Published: Sep 30, 2025

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