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Abstract

Present study was conducted to evaluate the various liver enzymes in experimentally induced enterotoxemic goat inorder to ensure the therapeutic potential of probiotics and antibiotics. Experiment was conducted at Department of Veterinary Medicine, Sindh Agriculture University Tandojam in which 35 non-descriptive goats were housed and experimenatally induced with enterotoxemia by inoculation of Clostridium perfringens culture surgically by performing laparotomy into intestine. After apperence of positive clinical signs of infection, goats were randomly divided into 5 treatment groups i.e. Group 1 (negative control), Group 2 (positive control), Group 3 (yogurt, 5 % solution, 50 mL/time), Group 4 (Yeast, 5 % solution, 50 mL/time), Group 5 (Filorphinocol, 50 mg/kg), Group 6 (Sulphadiazine/Trimethoprim + Yogurt), and Group 7 (Enrofloxacin + Yeast). Goats were monitored for 5 days post-induction of enterotoxemia and provided with specific treatments. Blood sample were taken after every 24 hours for performing liver function tests. The results showed significant hepatocellular damage in serum biochemical and liver function analysis in the positive control group, as indicated by markedly elevated enzyme levels (ALT: ~95 U/L, AST: ~150 U/L, ALP: ~220 U/L) at the onset of the study. Despite the decrease in enzymes gradually over the course of the experiment (ALT = 75 U/L, AST = 120 U/L, ALP = 180 U/L on Day 5), the findings indicated that the elevated values remained higher than the control values, implying that the liver cells were still under stress. On the contrary, the treated groups-maintained enzyme values higher initially but declined to physiological levels.

Article History

Received: Apr 16, 2026; Accepted: May 26, 2026; Published: June 30, 2026.

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