This study was undertaken to enumerate the medicinal plants of the area, find out the conservation status, and record the folk knowledge from the inhabitants of Turmic Valley during 2011-2013. The valley is located in the Rondo division of the District Skardu on the Northeastern side of the Indus River. The detailed information about the local flora regarding medicinal uses was collected from the local herbal healers (Hakeems) and other knowledgeable people. Locally used herbs of the area prevent and cure the people from various diseases such as joint pains, bronchitis, flu and fever, lowering blood pressure, constipation, liver disorders, stomach and abdominal problems, etc. The most common medicinal herbs found in the region belong to the families Gentianaceae, Berberidaceae, Umbelliferae, Labiatae, Rosaceae, Compositae, Urticaceae, and Ranunculaceae. The inhabitants of the valley mostly use the 42 plant species for the treatment of different health problems. Forty-two species of plants (including 4 Gymnosperms, 1 monocotyledon, and 37 dicotyledons) and 35 types of diseases have been identified during the current study. Thymus linearis, Rosa webbiana, Urtica dioca, Pleurospermum candollei, Berberis spp., Delphinium brononianum, and Mentha angustifolia were the commonly used plant species in the valley. The collected baseline data of this study will be helpfulfor young researchers in the fieldof taxonomy, ethnobotany, pharmacology, organic chemistry, and particularly for biodiversity conservation. Over exploitation, habitat destruction, and over grazing are the major threats for the loss of the important flora of the area.