Wildlife populations are at a risk of extinction mainly because of human-wildlife conflict (HWC). The present study was designed to evaluate the ongoing HWC with special reference to Common Leopard (Panthera pardus) in Ayubia National park through field study as well as a literature-based approach. Questionnaire interview surveys were designed for wildlife officials working in the park and the locals who bear the cost for leopard conflict through livestock depredation and crop damage. The study showed that human-leopard conflict in the study area has been increasing. More than 60% of people considered livestock depredation as the major reason for their negative perception towards the common leopard. Among livestock, goats were more vulnerable which showed that leopards mostly preferred smaller prey. A number of reported human injuries and deaths on account of Human-Leopard conflict in the study area helped conclude that human-wildlife conflict is a significant issue. Mitigation measures may hence be recommended, such as livestock compensation schemes and community-based conservation approaches, etc. It is critical to avoid human-Leopard conflict not only to keep the public and their property safe but also to help conserve this important species of common leopard (Panthera pardus).