Current Epidemiological Status and Antibiotic Resistance Profile of Urinary Tract Infection

Authors

Muddasir Khan, Centre of Biotechnology and Microbiology, University of Peshawar, Pakistan.Follow
Syed Hussain Shah, Department of Health and Biological Sciences, Abasyn University Peshawar, Pakistan.
M. Abdullah, Department of Health and Biological Sciences, Abasyn University Peshawar, Pakistan.
Muhammad Salman, Department of Health and Biological Sciences, Abasyn University Peshawar, Pakistan.
Fawad Hayat, Centre of Biotechnology and Microbiology, University of Peshawar, Pakistan.
Raheela Sarwar, Centre of Biotechnology and Microbiology, University of Peshawar, Pakistan.
Neelma Hassan, Department of Health and Biological Sciences, Abasyn University Peshawar, Pakistan.
Sohail Ahmad Jan, Department of Bioinformatics and Biosciences, Capital University of Science and Technology, Pakistan.
M. Saddam, Department of Microbiology, Abdul Wali Khan University, Mardan, Pakistan.
Ziaur Rahman, Department of Health and Biological Sciences, Abasyn University Peshawar, Pakistan.
Imran Qazi, Naseerullah Khan Babar Memorial Teaching Hospital Peshawar, Pakistan.

Abstract

With a longitudinal (2020–2021) completion, a set of 300 urine samples of individuals suspected of UTI was characterized based on the biochemical analysis and Kirby Bauer's disc diffusion method. Throughout, a total of 167 samples revealed UTI positivity by obtaining bacterial growth. Reporting that E. coli (69.4 %) was the most dominant when compared with Klebsiella (14.3 %), Proteus (5.9 %), S. aureus (4.7 %), P. aeruginosa (3.5 %), and Enterobacter (1.7 %), respectively. Gender-wise discrimination showed that E. coli was highly distributed among female (50.2 %) patients. A prominent percentage of E. coli (41.9 %) was found in the age group between 21-40 years. Isolates of E. coli represented the highest degree of resistance to Amoxicillin and Ceftriaxone (85.3 %), while highly sensitive to Amikacin, and Tazobactam (94.8 %). S. aureus was found highly resistant to Amoxicillin, Levofloxacin, Sulbactam, and Doxycycline (75 %), while highly sensitive to Meropenem, and Cefotaxime (100 %). Proteus spp. was found highly resistant to Sulbactam, and Cefotaxime (100 %), while highly sensitive to Tazobactam (100 %). Enterobacter was found highly resistant to Gentamicin (100 %), while highly sensitive to Aztreonam (100 %). Klebsiella was found highly resistant to Levofloxacin, and Doxycycline (91.6 %), while highly sensitive to Amikacin, Tazobactam, Gentamicin, and Cefoxitin (75 %). P. aeruginosa was found highly resistant to Nalidixic acid (100 %), while highly sensitive to Meropenem, Ceftriaxone, Gentamicin, and Cefotaxime. In conclusion, the Amikacin and Tazobactam were seen to be effective for empirical therapy of UTI.

Article History

Received: Nov 09, 2021; Accepted: Jan 14, 2022; Published: March 24, 2022

Recommended Citation

Khan, M., Shah, S. H., Abdullah, M., Salman, M., Hayat, F., Sarwar, R., Hassan, N., Jan, S. A., Saddam, M., Rahman, Z., & Qazi, I. (2022). Current Epidemiological Status and Antibiotic Resistance Profile of Urinary Tract Infection, Journal of Bioresource Management, 9 (1).