It has been recognized that gastric colonization with Helicobacter pylori (H. pylori) induces a risk of developing ulcer disease and gastric cancer. The interest of this research relates for the first time to the study of the Anti-Helicobacter pylori activities of three medicinal plants methanolic extracts, namely Allium sativum, Allium cepa and Foeniculum vulgare. The activity of the methanolic extracts was assessed against two strains of H. pylori (SAN158 and 26659) by the disc diffusion method on Muller Hinton agar. The content of phenolic compounds (TPC) was determined by the Folin-Ciocalteu test and the antioxidant activity was evaluated through the FRAP method (Ferric reducing antioxidant power). All plants extract were inhibitory towards both strains, with F. vulgare’s showing the strongest activity. The highest TPC, along with the best antioxidant capacity, was exhibited by the F. vulgare methanolic extract (1.44 mg GAE (gallic acid equivalents) / g ± 0.2 and 0.009 mg EAA (ascorbic acid equivalent) / g ± 0.001, respectively). This study showed that Allium sativum, Allium cepa and Foeniculum vulgare bioactive substances may be effective against Helicobacter pylori.

Article History

Received: Jan 31, 2022; Accepted: Sep 20, 2022; Published: Dec 17, 2022