The Monofactorial Model for Recurrence Risks with Generalized Penetrance

Authors

Harry J. Khamis, Wright State University - Main CampusFollow

Document Type

Article

Publication Date

1988

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Abstract

Recurrence risks are derived explicitly in terms of gene frequencies and penetrance coefficients for the general case in which all genotypes have incomplete penetrance. Maximum likelihood estimation of recurrence risks is achieved through the use of the semi-symmetric intraclass contingency table. The resulting formulas and estimation procedure can be useful for the analysis of population and family data, and in genetic counselling.

Repository Citation

Khamis, H. J. (1988). The Monofactorial Model for Recurrence Risks with Generalized Penetrance. Biometrical Journal, 30 (2), 209-222.
https://corescholar.libraries.wright.edu/math/171

DOI

10.1002/bimj.4710300214