Key Roles for AMP-Activated Protein Kinase in the Function of the Carotid Body?
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The carotid bodies play a critical role in initiating compensatory ventilatory responses to hypoxia. However, the complete mechanism by which hypoxia excites the oxygen-sensing carotid body type 1 cells has not been fully defined. We have previously proposed that the enzyme adenosine monophosphateactivated protein kinase (AMPK) may couple hypoxic inhibition of mitochondrial oxidative phosphorylation to carotid body type I cell excitation (Evans, Mustard, Wyatt, Peers, Dipp, Kumar, Kinnear and Hardie 2005). Here we discuss evidence that AMPK is a key requirement for hypoxic chemotransduction by the carotid body. In addition, we postulate upon a role for AMPK in the plasticity observed in the carotid body during both chronic and chronic intermittent hypoxia.
Wyatt, C. N.,
Pearson, S. A.,
Hardie, D. G.,
& Evans, A. M.
(2008). Key Roles for AMP-Activated Protein Kinase in the Function of the Carotid Body?. Advances in Experimental Medicine and Biology: Integration in Respiratory Control, 605 (2), 63-68.
Presented at the 10th Oxford Conference on Modeling and Control of Breathing, Lake Louise, Alberta, Canada.