Replication of Diabetogenic and Nondiabetogenic Variants of Encephalomyocarditis (EMC) Virus in ICR Swiss Mice
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The replication of the diabetogenic D (EMC-D) and nondiabetogenic B (EMC-B) variants of encephalomyocarditis virus in various tissues of the murine host was determined. Pancreatic insulin levels were also measured. EMC-D replicated in the spleen, pancreas, heart, lung, and intestines, while EMC-B was limited to the spleen and pancreas. EMC-B interfered with the replication of EMC-D in each of the tissues examined. Insulin levels were initially increased by both viruses. By 4 days postinfection, insulin levels were either normal or undetectable in (EMC-D)-infected animals, but were dramatically elevated in those infected with EMC-B.
Gould, C. L.,
Trombley, M. L.,
Bigley, N. J.,
McMannama, K. G.,
& Giron, D. J.
(1984). Replication of Diabetogenic and Nondiabetogenic Variants of Encephalomyocarditis (EMC) Virus in ICR Swiss Mice. Proceedings of the Society for Experimental Biology and Medicine, 175 (4), 449-453.