Specific Inhibition of RH0(D) Antibody by Sialic Acids
Agglutination of RhO(D) erythrocytes by specific antiserum was inhibited by crude and crystalline N-acetylneuraminic acid, less inhibited by its glycoyl derivative, and weakly inhibited by its degradation product, N-acetyl-mannosamine, and by D-mannose. A brain ganglioside containing neuraminic acid and a Pseudomonas polysaccharide were even more inhibitory. Inhibition was specific for anti-D sera.
Dodd, M. C.,
Bigley, N. J.,
& Geyer, V. B.
(1960). Specific Inhibition of RH0(D) Antibody by Sialic Acids. Science, 132 (3437), 1398-1399.