Glucocorticoids Pharmacology and Their Application in the Treatment of Childhood-Onset Systemic Lupus Erythematosus
Glucocorticoids are potent anti-inflammatory and immunosuppressant medications and remain the mainstay of systemic lupus erythematosus (SLE) therapy. The potency of a specific glucocorticoid, i.e., the dose of glucocorticoid that is required to produce a specific effect, is dependent on its pharmacokinetic (PK) and pharmacodynamic (PD) properties. In this review, we summarize the PK/PD properties of commonly used glucocorticoids in an attempt to better delineate their role in the management of children with childhood-onset SLE (cSLE). We also address glucocorticoid side effects as these play a major role when deciding on the dose, frequency, and duration of use. A better understanding of the pharmacology of glucocorticoids appears useful to achieve improved outcomes in the management of cSLE.
Chalhoub, N. E.,
Sherwin, C. M.,
& Bbrunner, H. I.
(2019). Glucocorticoids Pharmacology and Their Application in the Treatment of Childhood-Onset Systemic Lupus Erythematosus. Seminars in Arthritis and Rheumatism.