Alpha Melanocyte Stimulating Hormone Reverses Corticotropin-Releasing Hormone-Induced Sickness Behaviors in Infant Guinea Pigs
Prolonged maternal separation in infant guinea pigs is associated with the reduction of active behaviors such as locomotion and distress vocalizations, and with the onset of passive behaviors, such as immobility, crouching (a species-typical hunched posture), eye closing, and piloerection. Previous research indicates that the passive responses represent stress-induced sickness behaviors mediated by a systemic inflammatory response. For instance, we have previously shown that alpha melanocyte stimulating hormone (alpha-MSH; an anti-inflammatory agent) reverses separation-induced sickness behaviors. Because the passive responses can also be induced by corticotropin-releasing hormone (CRH), here we determined whether alpha-MSH could also reverse CRH-induced passive behaviors.
Schiml-Webb, P. A.,
Miller, E. E.,
& Hennessy, M. B.
(2005). Alpha Melanocyte Stimulating Hormone Reverses Corticotropin-Releasing Hormone-Induced Sickness Behaviors in Infant Guinea Pigs. Hormones and Behavior, 48 (1), 212, 126-126.