Title

Evidence for Amino Acid Concentration Gradients Between CSF and Extracellular Fluid

Document Type

Article

Publication Date

9-12-1994

Abstract

A small volume in the extracellular space of the medulla in the anesthetized cat was perfused with cisternal cerebrospinal fluid (CSF) using a push-pull technique. The recovered perfusate was a mixture of pushed CSF and the extracellular fluid. HPLC-EC analysis showed that the concentration of some primary amino acids in recovered perfusate often differed from their concentrations in CSF. These results suggested that amino acid gradients existed between CSF and the extracellular space.

DOI

10.1016/0304-3940(94)90758-7