The Effect of an H1 Blocker, Chlorpheniramine Maleate, on Total Menstrual Loss
50 subjects participated in a 4-month study of the effects of an antihistamine on total menstrual loss. During the first 2 periods, no drugs were given; during the last 2 periods, an antihistamine or a placebo was administered according to a double-blind format. The menstrual weights of the first 2 months were averaged and compared with averages from the last 2 months combined. The treated group showed an average decrease in menstrual loss of 11.30 g compared to a decrease of 0.98 g in the placebo group. While the difference in means was not statistically significant, the variance between the 2 groups was significant (p = 0.0002), indicating that the antihistamine, chlorpheniramine maleate, was effective in reducing menstrual loss in certain individuals, but that the effect was neither uniform nor universal.
Pendergrass, P. B.,
Scott, J. N.,
Ream, L. J.,
& Agna, M. A.
(1984). The Effect of an H1 Blocker, Chlorpheniramine Maleate, on Total Menstrual Loss. Gynecologic and Obstetric Investigation, 18 (5), 238-243.