Title

[3H]Ketanserin Binding Increases in Monkey Cortex Following Basal Forebrain Lesions With Ibotenic Acid

Document Type

Article

Publication Date

1986

Abstract

The present study investigated the effects of damage to the basal forebrain cholinergic system upon [3H]ketanserin binding in the neocortex and hippocampus of monkeys. [3H]Ketanserin specifically binds to serotonin type-2 receptor sites. Lesions were placed in the medial septal area, nucleus basalis, or both regions. Ten months later, [3H]ketanserin binding was increased in the neocortex, but not in the hippocampus, while levels of choline acetyltransferase (acetyl-CoA: choline O-acetyltransferase, EC 2.3.1.6) activity decreased in the neocortex and hippocampus. Changes in the levels of choline acetyltransferase and [3H]ketanserin binding were correlated significantly in the neocortex (r = −0.64, P < 0.025), but not in the hippocampus. The data suggest that degeneration of the basal forebrain cholinergic system may alter serotonergic function in the neocortex.

DOI

10.1016/0197-0186(86)90150-6