Diphenylene Iodonium Blocks K⁺ and Ca²⁺ Currents in Type I Cells Isolated from the Neonatal Rat Carotid Body

Authors

Christopher N. Wyatt, Wright State University - Main CampusFollow
E. K. Weir
Chris Peers

Document Type

Article

Publication Date

5-19-1994

Abstract

Diphenylene iodonium (DPI), an inhibitor of NAD(P)H oxidase, blocks hypoxic excitation of the carotid body. We use the whole-cell patch-clamp technique to investigate the actions of DPI on ionic currents in isolated type I carotid body cells. DPI (10 μM) caused reversible blockade of K⁺ and Ca²⁺ currents in these cells, indicating that DPI is a non-selective ion channel blocker. Since hypoxic excitation of the carotid body is dependent on Ca²⁺ influx into type I cells, our observation that DPI blocks Ca²⁺ currents in type I cells can account for the ability of this compound to inhibit hypoxic excitation of the intact organ.

Repository Citation

Wyatt, C. N., Weir, E. K., & Peers, C. (1994). Diphenylene Iodonium Blocks K⁺ and Ca²⁺ Currents in Type I Cells Isolated from the Neonatal Rat Carotid Body. Neuroscience Letters, 172 (1-2), 63-66.
https://corescholar.libraries.wright.edu/ncbp/854

DOI

10.1016/0304-3940(94)90663-7