Insulin-Like Growth-Factor Binding Protein (IGFBP) Serum Levels and Hepatic IGFBP-2 and -3 mRNA Expression in Diabetic and Insulin-Treated Swine (Sus scrofa)
1. Diabetes had no significant effect on IGFBP-3 message and serum levels however, subsequent insulin treatment caused more than a two-fold increase in both hepatic IGFBP-3 mRNA and serum levels above controls (P < 0.05).
2. The induction of diabetes in pigs significantly increased the steady state levels of IGFBP-2 mRNA in the liver of young swine (P < 0.05).
3. Both liver message and serum IGFBP-2 were reduced to control levels with insulin therapy.
4. We report here that in addition to its affects on IGFBP-2, insulin is involved in the regulation of IGFBP-3 expression.
White, M. E.,
Leaman, D. W.,
Ramsay, T. G.,
Kampman, K. A.,
Ernst, C. W.,
& Osborne, J. M.
(1993). Insulin-Like Growth-Factor Binding Protein (IGFBP) Serum Levels and Hepatic IGFBP-2 and -3 mRNA Expression in Diabetic and Insulin-Treated Swine (Sus scrofa). Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 106 (2), 341-347.