Title

Insulin-Like Growth-Factor Binding Protein (IGFBP) Serum Levels and Hepatic IGFBP-2 and -3 mRNA Expression in Diabetic and Insulin-Treated Swine (Sus scrofa)

Document Type

Article

Publication Date

10-1993

Abstract

1. Diabetes had no significant effect on IGFBP-3 message and serum levels however, subsequent insulin treatment caused more than a two-fold increase in both hepatic IGFBP-3 mRNA and serum levels above controls (P < 0.05).

2. The induction of diabetes in pigs significantly increased the steady state levels of IGFBP-2 mRNA in the liver of young swine (P < 0.05).

3. Both liver message and serum IGFBP-2 were reduced to control levels with insulin therapy.

4. We report here that in addition to its affects on IGFBP-2, insulin is involved in the regulation of IGFBP-3 expression.

DOI

10.1016/0305-0491(93)90311-R

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