ALS (also known as Lou Gehrig's Disease) is a neurodegenerative disease that weakens muscles and impacts physical function. The C9 Gene is responsible for creating proteins that help neurons send and receive signals across the synapse. Small Conductance calcium activated potassium channels (SK channels) affect the hyperpolarization phase of an action potential. Hypothesis: SK2 and SK3 clusters of C9 positive cells should decrease in size and intensity when exposed to a disease state compared to C9 negative controls.
Garrett, T. L.
(2023). Exploration of C9or72C9-500 SK2, SK3 Channel Expression. 2023 CoSM Festival of Research.