Sickle cell disease (SCD) is an inherited red cell disorder that leads to sickling of red blood cells, anemia and vaso-occlusion. The most common reason for hospitalization and morbidity in children is pain due to vaso-occlusive crisis (VOC). Importantly, poor sleep quality can lead to increased pain the subsequent day and nocturnal pain leads to reduced deep sleep, both which can then modify pain sensitivity. Studies using sleep diaries have shown this cyclical relationship between sleep and pain. Frequent occurrences of restless sleep are therefore believed to contribute to an increased severity and intensity of pain episodes. There is very little data, however, looking at objective data such as vital signs to define sleep in patients with SCD admitted for VOC. We aimed to make comparisons between sleep hours and daytime hours for pain scores, patient controlled analgesia (PCA) usage and vital sign data in effort to better define and understand sleep in SCD.
This research was originally published in Blood. Kalindi Narine, Fan Yang, Tanvi Banerjee, Jude Jonassaint, Nirmish Shah. Understanding Sleep in Pediatric Patients with Sickle Cell Disease Admitted for Vaso-Occlusive Pain Crisis through Objective Data. Blood. 2017;130:4791. © the American Society of Hematology.