Title

The Assessment Of Blood Loss During Total Knee Arthroplasty When Comparing Intravenous Vs Intracapsular Administration Of Tranexamic Acid

Document Type

Article

Publication Date

11-2016

Abstract

Background

Administration of tranexamic acid topically and intravenously has demonstrated effectiveness in decreasing blood loss and transfusion rates.

Methods

We randomized 131 patients undergoing primary total knee arthroplasty to receive either intracapsular (69) or intravenous tranexamic acid (62). Postoperative blood loss was calculated using the formula derived by Nadler et al. The number of units transfused was recorded, as well as length of hospital stay.

Results

We found no statistically significant difference on calculated blood loss (postoperative day [POD] 1: 624 ± 326 vs 644 ± 292; P = .71, POD 2: 806 ± 368 vs 835 ± 319; P = .64, and POD 3: 1076 ± 419 vs 978 ± 343; P = .55). There was no difference in number of blood transfusions, length of stay, or complications.

Conclusion

Intracapsular tranexamic acid is not inferior to intravenous tranexamic acid in decreasing blood loss and blood transfusion rate in primary total knee arthroplasty.

DOI

10.1016/j.arth.2016.04.018

Find in your library

Off-Campus WSU Users


Share

COinS