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We describe recent developments in an ongoing program to design work-centered C2 support for a military airlift organization. Work-centered design tailors support to the cognitive and collaborative demands of the work. A coordinated suite of visualizations was developed to support synchronized replanning in response to dynamically changing conditions by revealing the interrelationships and constraints across multiple missions distributed in time and space. Support included the ability to perform ‘what if’ simulations across multiple missions so as to assess the impact of a change in one mission on other missions. An empirical evaluation was conducted comparing target user replanning performance on multi-mission synchronization problems when using the new tool vs. a comparison tool representative of their current computer systems. The results revealed statistically significant improvements in solution times (three times faster), quality of solution (a third as many errors), situation awareness and workload, reinforcing the value of work-centered design.