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The purpose of this study is to determine whether any technology exists to unobtrusively, reliably, and accurately detect symptoms of fatigue in real time before fatigue affects performance. Airline pilots are fitted with a variety of physiological measurement devices (e.g. EEG, blink rate, etc.) that have been demonstrated in the literature to be related to fatigue. Each crew of two pilots performs simulated gate-to-gate flight operations under rested and fatigued conditions, during which physiologic and performance parameters are continuously monitored. In addition, audio, video, and simulator data are recorded for post-session evaluation. Ultimately, if one or more technologies proves effective, we can incorporate it into the flight deck for real-time fatigue detection capability as part of a larger fatigue risk management system. The usefulness of this type of approach extends beyond the commercial flight deck to any work environment that requires multi-shift or other non-traditional scheduling.