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Time-Based Flow Management (TBFM) seeks to enhance system efficiency by improving scheduling and interval management tools that expand and enhance the flow of traffic. This paper presents the results of an integrated human performance safety assessment of TBFM concepts planned for implementation between 2016 and 2020. The assessment utilized the Human and Organizational Safety Technique (HOST) to provide a structured method for identifying potential human error modes and estimating their contribution to the risk profile. HOST further defined graphical human-system interaction models for each proposed change and an integrated interaction model across all assessed TBFM changes. The HOST assessment resulted in multiple potential human error modes across the individual TBFM changes. As no concept will be implemented in isolation, key interactions among error mode interactions were assessed utilizing the integrated human and system interaction model. These findings directly influenced the development of Next Generation Air Transportation System (NextGen) safety requirements.