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With a unique high fidelity simulation lab, participants completed 3 hour work shifts to a run a simulated regional airline. The experimental design consisted of three teams randomly assigned to either a minimal, moderate, or maximum level of difficulty. Increases in workload and stress were implemented with various triggers and the participants had to quickly develop solutions to mitigate the problems. After the simulation, the participants completed the CATME (Comprehensive Assessment of Team Member Effectiveness) online survey for evaluations of their performance for five variables. (Ohland et al., 2012). Based on one-way analysis of variance (ANOVA), the results suggest only two components of teamwork were affected by workload and stress, expectation of quality and having relevant KSA’s. This leads to the conclusion that generally a team will perform based on their level of team cognition and efficient group behaviors, not necessarily based on the demands of workload and stress.